Metabolism of 14C-thiamethoxam in resistant and susceptible Colorado potato beetles

Colorado potato beetle is one of the principal pests of potatoes in the US and many places in the world. Neonicotinoid insecticides are the main choice to control the Colorado potato beetle. However, CPB has developed resistance to these compounds and is ranked as the 4th more resistance species to insecticides in the world. In order to effectively manage resistance, it is necessary to determine the mechanism of resistance. The rate of excretion and metabolism of14C- thiamethoxam in neonicotinoid resistant beetles was identified and compared with a susceptible strain.