Genetic basis of insensitivity to DEET in Anopheles gambiae

Monday, November 17, 2014: 9:36 AM
B110-112 (Oregon Convention Center)
James Ricci , Department of Entomology, University of California, Riverside, CA
David Turissini , University of California, Riverside, CA
Raissa Green , Institute for Integrative Genome Biology, University of California, Riverside, CA
Bradley White , Department of Entomology, University of California, Riverside, CA
Despite widespread and prolonged use, insensitivity to DEET has rarely been observed in mosquitoes. Also, DEET’s mode of action upon mosquitoes is still debated. We demonstrate significant variation in DEET sensitivity in a population of An. gambiae, and that this variation can be selected for over time. Continued selective pressures may produce wild populations insensitive to DEET. Genomic analysis of selected lines will reveal genes responsible for DEET insensitivity, and its mode of action.
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