Novel approaches to broaden the portfolio of chemical insecticides for control of adult malaria vectors

Control of malaria vectors relies heavily on the use of chemical insecticides. However, the effectiveness of current control strategies is being undermined by the evolution of insecticide resistance. This problem is exacerbated by the fact that only four classes of insecticide are approved by the WHO for use in domestic settings, creating limited options for effective resistance management. Here we outline some novel approaches to utilizing chemical insecticides that could create new opportunities for development of novel insecticides, or for repurposing existing insecticide products not currently used in vector control.