Genetic control of Aedes aegypti (L.)

The main vectors of dengue, Aedes aegypti and Aedes albopictus, are difficult to control with current methods but good potential targets of genetic control methods such as RIDL. In a RIDL control programme ‘sterile’ male mosquitoes are periodically released to mate with the target pest population; death of progeny due to inheritance of the RIDL transgene leads to population reduction.  The method is ‘self-limiting’; making it controllable and reversible, in contrast to ‘self-sustaining’ methods where the genetic change needs to persist in the wild population. Trials in the Cayman Islands 2009-2010 proved the technology could suppress an Aedes aegypti population, in that instance by 80% despite ongoing immigration from adjacent areas. Further trials in Brazil (2011-2012) provided equally positive results in different ecological and social settings.  Public acceptance of the technology at the field sites has been good.  Our experience of laboratory and field use of RIDL mosquitoes will be described