The response of dengue virus type 2 in Aedes aegypti to the infection with Metarhizium anisopliae

Dengue virus (DENV) is the arbovirus transmitted to humans most important worldwide. The primary vector is the mosquito Aedes aegypti. To be transmitted, the vector must ingest viremic blood meal which must be deposited in the midgut, infect and replicate in the midgut cells, go through the basal lamina, scatter in the homocele and finally invade the salivary glands, all pathway are essential for transmission. The entire process since the mosquito ingest the virus until it becomes infective is appointed extrinsic incubation period (EIP), and is very relevant epidemiologically. The only way to truncate the EIP is through vector contor which is carried out by chemical control. However, currently there is a new measure and vector control is the use of Metarhizium anisopliae which has shown promising results in laboratory.