The larvicidal effects of sterol carrier protein inhibitors (SCPIs) on the Colorado potato beetle (Leptinotarsa decemlineata)

Sterol Carrier Protein Inhibitors (SCPIs) have shown larvicidal effects on the yellow fever mosquito, Aedes aegypti, and the tobacco hornworm, manduca sexta. SCPIs have been suggested to inhibit the binding between Sterol Carrier Protein-2 (SCP-2) and cholesterol. In this study, we report that SCPIs have larvicidal activity to the colorado potato beetle, leptinotarsa decemlineata. 50% lethal concentration (LC₅₀) was 12.25 (8.94-16.05)μM, and larval development was also delayed significantly. However, SCPIs showed no toxic effect on adults. The result indicate that SCPIs are potent larvicides for the colorado potato beetle.