The ectoparasitic scabies mite, Sarcoptes scabiei, is the source of immunmodulating molecules that likely are responsible for suppressing the host’s immune response to the parasite allowing it to establish an infestation. Scabies extract was fractionated by isoelectric focusing (IEF) followed by anion exchange chromatography. The immunmodulating molecules have pIs of 4 – 5 and are eluted from an anion exchange column after the major protein peak.