Tuesday, December 12, 2006

Flubendiamide: The next generation in Lepidoptera pest management

Shane Hand, shane.hand@bayercropscience.com, M. Learned, mac.learned@bayercropscience.com, A. Kurokawa, arlene.kurokawa@bayercropscience.com, D. Palrang, drew.palrang@bayercropscience.com, and M. Mahoney, matt.mahoney@bayercropscience.com. Bayer CropScience, R&D, 2 TW Alexander Drive, Research Triangle Park, NC

Flubendiamide (proposed) is a new, lepidopteran insecticide that is being developed by Bayer CropScience for use in broad number of annual and perennial crops. Researched under the experimental code number NNI-0001, flubendiamide is the first member of a new chemical class, the phthalic acid diamides.

The novel biochemical mode of action of flubendiamide exhibits excellent larvicidal activity as an orally ingested toxicant by targeting and disrupting the Ca2+ balance. This results in rapid cessation of feeding and extended residual control, providing superior plant protection against a broad-range of economically important lepidopteran pests, including Helicoverpa spp., Heliothis spp., Spodoptera spp., Plutella spp., Pseudoplusia spp., Trichoplusia spp., and Agrotis spp. As a new mode of action, flubendiamide exhibits no cross-resistance to conventional chemistries.

Experiments in North America have shown flubendiamide to be hydrolytically stable, relatively immobile in soils, practically non-detectable in key rotated crops, mobile in the xylem following penetration into plant tissue, and exhibits strong rainfast characteristics due to the unique chemical properties

Flubendiamide has a favorable ecological, ecotoxicological and environmental profile with low acute mammalian toxicity and no genotoxic, mutagenic or oncogenic properties noted.

Flubendiamide will have an excellent fit in Integrated Pest (IPM) and Insecticide Resistance Management (IRM) programs in a variety of crops because of the many favorable characteristics, including selective activity against a broad range of lepidopteran pests, a new mode of action, safety to pollinators/beneficials, a favorable environmental and ecological (low toxicity) profile, short REI/PHI, and low use rates for less environmental loading.

Species 1: Lepidoptera Noctuidae Trichoplusia ni (cabbage looper)
Species 2: Lepidoptera Noctuidae Helicoverpa zea (cotton bollworm, corn earworm)
Species 3: Lepidoptera Noctuidae Spodoptera frugiperda (fall armyworm)