Results are reported for field trials with the AdvanceŽ termite bait system in Columbus, Ohio (Franklin County) at four structures infested with the eastern subterranean termite, Reticulitermes flavipes. Termites quickly occupied the monitoring stations, with at least one infested station noted 1 to 2 months after station installation at all four sites. During the subsequent baiting phase (active ingredient, 0.25% diflubenzuron), termites infested additional monitoring stations at all sites, which allowed the installation of additional bait cartridges. Termites readily consumed the AdvanceŽ bait matrix, resulting in a relatively rapid decline then cessation of colony activity, typically within several months. This study, which has been ongoing since April 2005, indicates that the AdvanceŽ termite bait system showed efficacy against R. flavipes, which readily occupied stations and consumed the bait matrix resulting in colony elimination.