The indoxacarb-based bait Advion™ was developed for the control of the red imported fire ant (RIFA), Solenopsis invicta Buren. This bait capitalizes on the complex trophallaxis-driven social feeding behavior of the RIFA. It is believed that within the RIFA colony indoxacarb, which must first be metabolized by the insect in order to become acutely toxic, is metabolized by the larvae, though the ability of the other castes to metabolize indoxacarb was unknown. There was no significant difference (P>0.05) in mortality between replicates with workers only and replicates with both workers and brood, and both treatments resulted in ~82% worker mortality by 7d, thus indicating that the workers were capable of metabolizing indoxacarb into the acutely toxic metabolite.