Indoxacarb-containing Advion™ is a bait developed for the control of the red imported fire ant (RIFA), Solenopsis invicta Buren. To date, only limited research has been conducted which compares the effectiveness of Advion™ to other RIFA baits, and no research has been conducted to analyze the effectiveness of Advion™ when used in a pre-baiting broadcast treatment. The concept of pre-baiting involves treatment with non-toxic bait in order to stimulate feeding activity prior to treatment with toxic bait, or to dilute the bait in order to get even distribution of the active ingredient. Both pre-baiting broadcast treatment and label-rate broadcast treatment with 0.045% Advion™ resulted in the same overall level of RIFA colony mortality (98-99%), which was significantly greater (P,0.05) than that resulting from treatment with Amdro® (87%). Ultimately, label-rate broadcast treatment with 0.045% Advion™ was determined to be the most effective treatment due to the fact that it resulted in an LT90 of only 6.2 d, compared to the 11.7 d LT90 resulting from the pre-baiting broadcast treatment.