Epidemics of tomato spotted wilt caused by Tomato spotted wilt virus vectored by Frankliniella occidentalis and possibly other thrips including F. bispinosa occur regularly in tomato in the southeastern US. We conducted research that resulted in the development of an integrated pest management program. Most incidence of the disease is the result of primary infection where larval thrips acquire the virus when developing on infected weed or crop hosts growing outside the tomato field. The adults migrate into the tomato field and transmit the disease. The use of highly ultraviolet-reflecting plastic mulch is effective in reducing the influx of such thrips and primary infections of disease. The plant activator acibenzolar-S-methyl further reduces tomato spotted wilt incidence. Reproduction of thrips on tomato is poor, but their control is effective in preventing secondary infections. The combination of ultraviolet-reflecting mulch, acibenzolar-S-methyl, and insecticides is very effective in reducing tomato spotted wilt incidence in tomato.