The development of new insecticides has resulted in the commercialization of many new compounds that have a very favorable environmental risk and mammalian toxicology profiles and it is expected that this trend will continue into the future. However, many insecticides (and nematicides) generally regarded as being toxic, still have an excellent efficacy profile against specific pests coupled with low per acre use rates. Such products can potentially benefit from the use of a completely closed delivery system that minimizes worker exposure, environmental impacts and effects on non-target species. An example of a completely closed system is AMVAC’s SmartBox system that is currently being used in corn for the control of corn rootworms and other yield reducing pests. SmartBox will have wider applications when matched up with other compounds for use in crops other than corn especially when utilizing the inputs of precision agriculture. A review of the elements of the SmartBox system and the future developmental projects based on geographical information systems and new delivery concepts will be discussed. It is expected that the availability of the new and improved SmartBox system will help mitigate safety concerns with existing products as well as provide potential solutions for future development of new products.