The nuclear protein, proliferating cell nuclear antigen (PCNA), is essential for multiple cell cycle pathways including DNA replication, DNA elongation, and base excision repair. Although the PCNA gene has been sequenced from some insects, this is the first example from a mosquito. We sequenced a 1083 bp cDNA from Aedes albopictus that encoded a protein with 90% identity with PCNA from Drosophila melanogaster. On western blots, the protein had a mass of 35 kDa.
Species 1: Diptera Culicidae Aedes albopictus (Asian tiger mosquito)
Keywords: cell cycle, DNA repair
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