Interplay of population genetics and dynamics in the genetic control of mosquitoes
The population genetics of HEG-based systems have been established using discrete-time mathematical models. However, these only form part of our understanding of this approach to vector control, as several ecologically important aspects remain unexplored (overlapping generations, density-dependent non-linear larval competition, relative timing). We formulate a new continuous-time combined population dynamic and genetic model and apply it to the case of a HEG that targets (and knocks out) a gene that is essential for survival.
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