Inheritance of resistance to deltamethrin in Aedes aegypti (Diptera: Culicidae) from Cuba

The development of pyrethroid resistance in Aedes aegypti is a serious concern since major Ae. aegypti Control Programs are predominantly based on pyrethroid use in epidemic conditions. Research about the pyrethroid resistance and how it is transmitted to the further generations are needed.  Here a field population of Aedes aegypti (L) from Santiago de Cuba, selected for 14 generation of selection with high deltamethrin resistance level (87.5x) was cross and backcross with the Ae. aegypti susceptible strain Rockefeller.  Logit regression analysis of F1 reciprocal crosses between SAN-F14 and Rockefeller indicated that sex linkage of resistance did not occur and that the genetic basis of the deltamethrin resistance was autosomal inheritance, incompletely dominant (DLC= 0.72) trait. A direct test of monogenic inheritance based on a back-cross of F1 progeny with SAN-F14 suggested that resistance to deltamethrin was controlled by more than one factor. Synergists and biochemical assays indicated that the metabolic enzymes are involved in the deltamethrin resistance.

Presentation.  Poster.

 

KEY WORDS: Aedes aegypti, deltamethrin, inheritance, synergist.