DuPont Rynaxypyr™ (DPX-E2Y45) is the first active ingredient from a novel class of insecticides, the Anthranilic Diamides. Rynaxypyr™ has a new mode of action and acts very selectively as a potent agonist of insect ryanodine receptors (group 28, IRAC International). Rynaxypyr™ has proven effective against a wide range of lepidopteran pests, as well as additional key pest species within the orders Coleoptera, Hemiptera, Diptera, and Isoptera. In over 4,000 development field trials around the world and numerous laboratory experiments in 18 countries, no evidence has been found of cross-resistance between Rynaxypyr™ and existing insecticides. These results show that Rynaxypyr™ will control insect populations that have developed resistance to other insecticides, thus creating a fit for Rynaxypyr™ as a rotational partner in insect resistance management programs.