Insect-vectored diseases cause serious losses in many agricultural crops worldwide. Improved understanding of the complex interactions among plants, pathogens, and insect vectors should inform the development of effective and sustainable disease management strategies, which often focus on manipulating vector populations to limit opportunities for pathogen transmission. The impact of infection on plant quality and attractiveness to insect vectors is a key issue, and the dependence of pathogens and herbivores on a common host plant creates the potential for both mutualistic and antagonistic interactions. This study examined the effects of cucumber mosaic virus (CMV) infection in tomato and squash by measuring the production of plant volatiles and assessing the growth and reproduction of a common aphid vector, Myzus persicae, on healthy and infected plants. In both tomato and squash plants CMV infection increased total volatile production per unit of leaf tissue and induced qualitative changes in the volatile blend emitted. Initial assays of aphid growth on CMV infected squash plants revealed a trend toward increased production of alates relative to healthy plants. These results suggest that CMV infection has extensive effects on plant chemistry that can influence aphid vectors in ways that may affect disease transmission.