A revision of the genus Sisenes Champion (Coleoptera: Oedemeridae) is provided using comparative anatomical morphological characters of adults. The revision is based on a taxonomic analysis of 35 species historically attributed to the genus and a cladistic analysis of the 22 species I hypothesize to be correctly assigned to Sisenes and a related new genus. Nine trees were produced in a heuristic search, with all characters unweighted and unordered. Synapomorphies for the newly defined Sisenes include: apical segment of maxillary palpus short, cultriform, antennal segments 3-5 thickened/broadened, elytra slightly widened apically, elytra with four costae, and striae strongly impressed. Ten species comprise the genus as now defined. Two species remain inserte sedis due to missing types and lack of adequate study material. Twelve species are removed from the historical Sisenes and placed into the proposed new genus, Cantharosisenes. Six species are removed from the historical Sisenes and placed into existing genera. Four new synonyms are proposed.