Clothianidin insecticide is marketed as a seed-coating treatment of corn kernels for protecting root tissues from rootworm larvae and other secondary insect pest feeding. Antidotal reports exist that indicate a yield boost is occurring in corn fields with this seed treatment. Trials were conducted at 3 locations in 2004 in eastern South Dakota. Also, additional rootworm injury data will be collected during 2005 in 3 additional study sites. Preliminary results in 2004 did little to substantially confirm or rule-out any yield enhancement from this clothianidin-treated plot in our state. However, at one location where rootworm populations were below threshold levels, a significantly greater yield was obtained in clothianidin-treated plots as compared to that found in the untreated plots. It should be noted that this research study is part of a much larger investigation on this issue in many states and conducted under a cooperative regional investigation by the North Central NCR-46 corn rootworm committee.