The 2005 ESA Annual Meeting and Exhibition
December 15-18, 2005
Ft. Lauderdale, FL

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Saturday, December 17, 2005 - 1:54 PM
0912

Induction of aflatoxin B1-metabolizing cytochrome P450 monooxygenases in Helicoverpa zea by plant signaling compounds and allelochemicals

Rensen Zeng, rszeng@life.uiuc.edu1, Guodong Niu, gniu@life.uiuc.edu2, Zhimou Wen, zwen@life.uiuc.edu2, Mary Schuler, maryschu@uiuc.edu2, and May R. Berenbaum, maybe@life.uiuc.edu2. (1) University of Illinois at, Urbana-Champaign, Entomology, 320 Morrill Hall, 505 S. Goodwin Ave, Urbana, IL, (2) University of Illinois at Urbana-Champaign, Entomology, 320 Morrill Hall, 505 S. Goodwin Av, Urbana, IL

Aflatoxins are carcinogenic mycotoxins produced by Aspergillus flavus and A. parasiticus infecting certain grains including corn. In this study we investigated the induction of aflatoxin B1-metabolizing cytochrome P450 monooxygenases by plant signaling compounds and allelochemicals in the corn earworm Helicoverpa zea. Salicylic acid (SA) increased toxicity of the mycotoxin, while allelochemical indole-3-carbinol reduced toxicity of the mycotoxin. These results suggest that SA induced P450s that bioactivate aflatoxin B1 and indole-3-carbinol induced P450s that detoxify the mycotoxin. The disposition of aflatoxin B1 in H zea may involve multiple P450s.


Species 1: Lepidoptera Noctuidae Helicoverpa zea (Corn earworm)
Keywords: aflatoxin, metabolism

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