Lymphatic filariasis (Elephantiasis) affects over 120 million people in 80 countries, with 1.2 billion people at risk worldwide. Over 90% of infections are caused by Wuchereria bancrofti, for which humans are the exclusive host. History suggests that elimination of lymphatic filariasis in Polynesia is unachievable without control of the primary mosquito vector: Aedes polynesiensis. Since mosquitoes are obligate vectors of W. bancrofti, this suggests an approach for filariasis elimination: eradication of the mosquito vectors will break the disease transmission cycle. Unfortunately Ae. polynesiensis currently cannot be controlled, much less eradicated. I will propose a strategy in which releases of male Ae. polynesiensis mosquitoes infected with Wolbachia bacteria result in the sterilization of female mosquitoes at a field site endemic for filariasis transmission. Intracellular Wolbachia bacteria are obligate, maternally-inherited endosymbionts found frequently in insects and other invertebrates. In mosquitoes, Wolbachia causes a form of sterility known as cytoplasmic incompatibility (CI). In the proposed strategy, repeated releases of CI males will be used in the eradication of the targeted Ae. polynesiensis population. This strategy is similar to a prior field trial that targeted Culex mosquitoes in Burma. The proposed strategy employs a naturally occurring bacteria infection and does not include genetically modified organisms. I will describe the generation of a Wolbachia-infected Ae. polynesiensis strain that sterilizes female mosquitoes from Maupiti in laboratory cage tests. I will also review recently developed techniques permitting the generation of new Wolbachia infection types in mosquitoes via microinjection.