Conservation of natural enemies using selective insecticides contributes to the success of Integrated Pest Management (IPM) programs for many cropping systems. In this study, we evaluated the toxicity of two commonly used selective insecticides, indoxacarb and spinosad, in sweet corn and soybean to the multicolored Asian lady beetle,Harmonia axyridis (Pallas). Third instars and adults of H. axyridis were exposed to indoxacarb at 50 and 100% of the field rate (FR), spinosad at 100% FR, and water (untreated check) under laboratory conditions via three routes of exposure. Treatments were applied directly on insects (topical application), on Petri dishes (insecticide residues), or on dead soybean aphids, Aphis glycines Matsumara, (treated prey). Mortality of treated individuals in each life stage was recorded 2 and 7 d after treatment. Third instars and adults were susceptible to indoxacarb at both rates via all routes of exposure. However, mortality was highest when beetles were exposed to indoxacarb via residues, followed by treated prey. Third instars were only slightly susceptible to spinosad when exposed to residues. Adults were tolerant to spinosad via all routes of exposure. Our results confirm that different routes of exposure may affect the toxicity of indoxacarb and spinosad to H. axyridis.