Stored product insect pests that infest commodity in mills, warehouses and food storage facilities can cause substantial economic and quality losses. Since, these insect pests can be found anywhere within the facilities, localized treatment or physical methods may not adequately control the pests. Therefore, fumigation is the preferred method of control. Methyl bromide has been the fumigant of choice in many of the commodity processing facilities. However, this product, identified as an ozone depleting chemical, is being phased out under Montreal Protocol. ProFume gas fumigant, developed by Dow AgroSciences as an alternative to methyl bromide was granted registration by USEPA in January 2004. First commercial fumigation using ProFume was conducted in April 2004. Since that time many commercial fumigation were successfully completed by certified fumigators in many regions of the United States. These facilities include, rice mills, wheat mills, corn mills, etc. This paper summarizes the performance success of ProFume gas fumigant under variable conditions.