Data from DNA fingerprinting of bloodmeals indicate that Aedes aegypti take a greater proportion of bloodmeals from adults than from children. Age-dependent biting rates could result in age-dependent force of infection. If force of infection increases with age then we would expect the control effort necessary to interrupt virus transmission to be underestimated by an age-independent model. To test this hypothesis, we estimated age specific force of infection for dengue viruses in Iquitos, Peru from a cohort of schoolchildren and their families using longitudinal serological data from 1999-2003. Force of infection was found to be significantly higher in older age groups during the interepidemic period with 18% of susceptibles over 15 years seroconverting and only 9% of susceptibles under 9 years seroconverting (p<0.001). However, during the dengue 3 epidemic beginning in late 2001, the force of infection dramatically increased for all ages with nearly 40% seroconverting. In that different epidemiological circumstance, the age difference was not significant, possibly due to the sampling interval of six months. A susceptible-infectious-immune simulation model will be presented to estimate the basic reproductive number of dengue viruses in an age-structured popuation and to determine the effect of heterogeneous transmission on control effort efficacy.