Although significant progress has been made in containing the spread of Miconia calvescens in Hawaii using herbicides, biological agents introduced from the neotropics, where miconia is native, are necessary for long-term management of this potentially devastating invader. Because miconia is fast-growing, long-lived, woody, and highly fecund with a durable seed bank, the difficulty of attaining successful biocontrol should not be underestimated. We are developing a suite of biocontrol agents that attack miconia plants in a variety of ways. Potential agents from Brazil and Costa Rica have been prioritized for study based upon the strength of their expected impacts. They include two pathogens: a leaf pimple fungus (Coccodiella miconiae) and a gall producing nematode (Ditylenchus sp.). Insects to be evaluated include a homopteran shoot feeder (Diclidophlebia lucens, Psyllidae), defoliators (Euselasia chrysippe, Lycaenidae; Antegumia sp., Pyralidae; Druentia cf. inscita, Mimallonidae; and Atomacera petroa, Argidae), a stem boring weevil (Cryptorhynchus melastomae, Curculionidae), a lepidopteran flower feeder (Thecla opisena, Lycaenidae), and a fruit feeding weevil (Anthonomus monostigma, Curculionidae). Our goal is to reduce seed production, slow growth, and increase mortality of immature and mature trees, impacting miconia to a point that it requires either no additional management or a level management that is sustainable.