A variety of plant and insect treatment combinations were evaluated as to their ability to prevent/limit Pierce's disease of grapes. A combination of neonicotinoids (imidacloprid plus acetamiprid) and kaolin film provided the best protection against glassy-winged sharpshooter, reducing densities by approximately 90%. The same treatment combination reduced sharpshooter oviposition by 75%. Egg parasitism was unaffected by any of the treatments. The layering of neonicotinoids and kaolin limited the incidence of PD to 30% after 18 months, but PD incidence climbed to above 70% in all treatments after 30 months. Antibiotic therapy (metalosate), alone or in combination, did not affect PD incidence