Only a few cockroach species are truly pestiferous, infesting man-made structures where food, water, and shelter are readily available. In some cases, cockroach infestations occur in sensitive environments, such as schools, daycares, nursing homes, zoos, and animal rearing facilities, where conventional pest management may not be an option. Here we report on pest management in two sensitive environments: a swine production facility and a museum conservatory housing several live butterfly species, hummingbirds, turtles, and a two-toed sloth. Insect growth regulators mixed with a pyrethroid insecticide were used to reduce and manage German cockroach populations in the farrowing barns of a swine production facility. After an initial knockdown by the pyrethroid, the residual action of the juvenile hormone analogs resulted in population maintenance well below threshold. In the museum conservatory, insecticide gel bait placed in PVC containers was used to manage a simultaneous infestation of three cockroach species. Bait tubes were designed to allow access by the cockroaches to the gel bait, but to exclude all other vertebrates and invertebrates housed in the conservatory. In both studies, cockroach populations were significantly reduced following treatment with no observable non-target effects.