House mice, Mus musculus, are potential reservoirs of zoonotic diseases and ectoparasites. Most consumers assume that mice sold from pet stores are safe and parasite free. We purchases two frozen mice from pet stores in South Carolina and examined them for ectoparasites. All mice were infested with one or more of the following ectoparasites; Acaridae, Liponyssoides sanguineus,Myocoptes musculinus, Myobia musculi, Ornithonyssus bacoti, Polyplax serrata, and Radfordia affinis. Both Liponyssoides sanguineus and Ornithonyssus bacoti are potential vectors of zoonotic pathogens. The presence of ectoparasites on mice implies that other pets could be infested with ectoparasites.