There has been a long history of cultivation of oriental persimmon (Diospyros kaki) on the island of Maui in Hawaii. One persistent problem has been loss through infestation by the Mediterranean fruit fly, Ceratitis capitata (Wiedemann), which became established in Hawaii in 1910. Mediterranean fruit fly populations are maintained throughout the year through a succession of “bridge” hosts, with fly populations moving from one host to another as each crop comes into season. In order to minimize infestation in persimmon, the Mediterranean fruit fly population was suppressed using mass deployment of traps baited with a 3-component synthetic protein bait. Traps were initially placed in adjacent host trees (peach, loquat, plum, and citrus species) which bore fruit before persimmon season started. Good population suppression was achieved in most persimmon orchards because many of the flies generated from earlier fruiting alternate hosts were “cleaned out” of the orchards before persimmon fruits became susceptible to sting damage. However, on a farm where fruiting of a favored alternate host, coffee, began before persimmon season and continued bearing throughout persimmon season, the mass-trapping approach did not adequately suppress the Mediterranean fruit fly population. We present results of the mass trapping trial and a trial where weekly applications of a spinosad-based protein bait spray were applied to coffee plants so as to reduce Mediterranean fruit fly infestation in the adjacent persimmon orchard. The success of the suppression trials have encouraged consideration of reintroduction of low-chill peaches which had been abandoned earlier because of high infestation levels.