Insects have a rigid exoskeleton. Continuous growth therefore requires the periodic replacement of the cuticle of one stage with a larger one for the next stage. Molting, the process of making a new cuticle, culminates with ecdysis, a stereotyped sequence of behaviors used to shed the old cuticle from the previous stage. Ecdysis behavior, as well as other related physiological events expressed at ecdysis, are controlled by several interacting neuropeptides: Ecdysis Triggering Hormone (ETH), Eclosion Hormone (EH), and Crustacean Cardioactive Peptide (CCAP). We have used wildtype Drosophila as well as transgenic flies bearing targeted ablations of either EH or CCAP neurons, or ablations of both together, to examine the functional relationships between ecdysis controlling neuropeptides. We show that the known neuropeptides control ecdysis via partially redundant mechanisms, and also propose that important additional neuropeptides may contribute to the mechanisms underlying insect ecdysis behaviors. In many insect species, the circadian clock restricts the time of adult ecdysis (eclosion) to specific times of day. We have started investigating how the circadian clock restricts adult eclosion to specific times of day by examining the relationship between the titers of the steroid molting hormone, 20-hydroxy-ecdysone, time of day, and progression through the molt.