Ecdysone receptor (EcR) and its heterodimer ultraspiracle protein (USP) are members of the nuclear receptor superfamily and are ligand-activated transcriptional factors. Studies of other transcriptional factors in vertebrates have shown that phosphorylation can play important roles in nuclear translocation, ligand- and DNA-binding, protein-protein interactions and transactivation. In this study, the effect of JH, 20E and cAMP on the phosphorylation of USP and EcR and the function of the EcR/USP complex were investigated in the salivary glands of both wild type and ecdysone-deficient mutant without childrenrgl (wocrgl) of Drosophila melanogaster.
Species 1: Diptera Drosophilidae Drosophila melanogaster (pomace fly)
Keywords: JH and 20E, nuclear receptor
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