Wednesday, 20 November 2002
D0624
This presentation is part of : Display Presentations, Section D: Medical and Veterinary Entomology
Effectiveness of optically active insect repellent (1S,2S')-2-methylpiperidinyl-3-cyclohexene-1-carboxamide (SS-220) compared to Deet and Bayrepel®
Jerome A. Klun1, Ashot Khrimian1, Armenak Margaryan1, Matthew Kramer2, and Mustapha Debboun3. (1) USDA-ARS, Chemicals Affecting Insect Behavior Laboratory, Beltsville Ag. Res. Center, 10300 Baltimore Ave, Beltsville, MD, (2) USDA-ARS, Biometrical Consulting Service, Beltsville Ag. Res. Center, 10300 Baltimore Ave, Beltsville, MD, (3) Walter Reed Army Institute of Research, Department of Entomology, Building 503, Robert Grant Avenue, Walter Reed Army Medical Center, Washington, DC
The compound (1S, 2'S)-2-methylpiperidinyl-3-cyclohexen-1-carboxamide (SS220) could serve as
new alternate repellent for protection against blood-feeding arthropods . A three-step scheme was
employed to synthesize SS 220. This synthetic method represents a major organic synthesis
improvement and it is suitable for scale-up and preparation of large quantities of the compound.
K&D module laboratory assays tested the effectiveness of SS220 as a deterrent to biting mosquitoes
compared to Deet and Bayrepel. Results indicated that SS220 is as effective or more effective than the two commonly used repellents.
Species 1: Diptera Culicidae Aedes aegypti (yellow fever mosquito)
Species 2: Diptera Culicidae Anopheles stephensi
Keywords: mosquito repellent
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