Insulin receptor (InR) mutant Drosophila are smaller in size, slow in development, female infertile and long-lived. In vitro incubation of corpora allata and ovaries of the InR mutants also shows that they have much lower Juvenile hormone (JH) and ecdysone syntheses compared to the coisogenic wildtype. Thus, neuropeptides in regulating JH and ecdysone syntheses are either directly or indirectly affected by the InR signaling pathway. The immunolocalization of some neuropeptides was done in both wildtype and InR mutants in this study. The nutirion manipulation was also used to study the possible role of InR in regulating fly reproduction.
Species 1: Diptera Drosophilidae Drosophila melanogaster (fruit fly)
Keywords: Immunocytochemistry
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